C₃₁H₃₈Cl₂FN₅O₅

Base Information

• Chemical Name: C₃₁H₃₈Cl₂FN₅O₅
• CAS No.: 1569895-72-2
• Molecular Formula: C₃₁H₃₈Cl₂FN₅O₅
• Molecular Weight: 650.578
• Mol file: 1569895-72-2.mol

Synonyms:C₃₁H₃₈Cl₂FN₅O₅

Chemical Property of C₃₁H₃₈Cl₂FN₅O₅

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₃₁H₃₈Cl₂FN₅O₅

There total 1 articles about C₃₁H₃₈Cl₂FN₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (877399-50-3) → C31H38Cl2FN5O5 (1569895-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 12 h / 20 - 30 °C

1.2: 6 h / 20 - 30 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide; water / 3 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; isopropylmagnesium chloride; sodium carbonate; lithium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;

DOI:10.1016/j.tetlet.2014.01.053

Reference yield: 99.6%

C31H38Cl2FN5O5 (1569895-72-2) → crizotinib (877399-52-5)

Guidance literature:

With hydrogenchloride; In ethanol; dichloromethane; water; at 0 - 20 ℃; for 12h;

upstream raw materials:

4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

crizotinib

Refernces