PZ₁₀₅₇-2

Base Information

• Chemical Name: PZ₁₀₅₇-2
• CAS No.: 1398718-72-3
• Molecular Formula: C₃₆H₄₆N₆O₄
• Molecular Weight: 626.799
• Mol file: 1398718-72-3.mol

Synonyms:PZ₁₀₅₇-2

Chemical Property of PZ₁₀₅₇-2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PZ₁₀₅₇-2

There total 3 articles about PZ₁₀₅₇-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(S)-tert-butyl 1-(1-cyano-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate (1352152-51-2) + C15H18BrN3O (1398718-70-1) → PZ1057-2 (1398718-72-3)

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

1-(4-bromobenzyl)piperazine (91345-62-9) → PZ1057-2 (1398718-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Microwave irradiation

With sodium cyanoborohydride; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → PZ1057-2 (1398718-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Microwave irradiation

With sodium cyanoborohydride; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(4-bromobenzyl)piperazine

4-bromo-benzaldehyde

(S)-tert-butyl 1-(1-cyano-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate

C₁₅H₁₈BrN₃O

Downstream raw materials:

(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Refernces