[(4-Methoxyphenyl)methyl](diphenyl)phosphane

Base Information

• Chemical Name: [(4-Methoxyphenyl)methyl](diphenyl)phosphane
• CAS No.: 896-89-9
• Molecular Formula: C19H17 O P
• Molecular Weight: 292.317
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID30503458
• Wikidata: Q82357290
• Mol file: 896-89-9.mol

Synonyms:[(4-Methoxyphenyl)methyl](diphenyl)phosphane;Phosphine,(4-methoxyphenyl)diphenyl-;(4-methoxyphenyl)methyl-diphenylphosphane;SCHEMBL381509;DTXSID30503458

Chemical Property of [(4-Methoxyphenyl)methyl](diphenyl)phosphane

Chemical Property:

• Melting Point: 124-126℃
• Boiling Point: 394.5±25.0 °C(Predicted)
• PSA: 22.82000
• LogP: 3.45340
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 306.117352223
• Heavy Atom Count: 22
• Complexity: 281

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CP(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of [(4-Methoxyphenyl)methyl](diphenyl)phosphane

There total 34 articles about [(4-Methoxyphenyl)methyl](diphenyl)phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-4-methoxy-benzene (104-92-7) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (4-methoxyphenyl)diphenylphosphane (896-89-9)

Guidance literature:

1-bromo-4-methoxy-benzene; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; for 2h; Inert atmosphere;

Reference yield: 93.0%

4-(diphenylphosphoryl)benzonitrile (795-44-8) → (4-methoxyphenyl)diphenylphosphane (896-89-9)

Guidance literature:

With trichlorosilane; In tetrahydrofuran; toluene; at 110 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115310

Reference yield: 90.0%

1-bromo-4-methoxy-benzene (104-92-7) + diphenylphosphane (829-85-6) → (4-methoxyphenyl)diphenylphosphane (896-89-9)

Guidance literature:

diphenylphosphane; With N,N’-dimethyl-2,6-bis(aminomethyl)pyridine; copper(l) iodide; In toluene; Glovebox; Schlenk technique; Inert atmosphere;

1-bromo-4-methoxy-benzene; With potassium tert-butylate; In tetrahydrofuran; toluene; at 100 ℃; for 24h; Schlenk technique; Sealed tube;

DOI:10.1007/s11164-018-3403-3

upstream raw materials:

chloro-diphenylphosphine

4-methoxyphenyl magnesium bromide

1-bromo-4-methoxy-benzene

sodium diphenylphosphide

Downstream raw materials:

-p-anisyl-diphenyl-phosphazin

Diphenyl-(4-methoxy-phenyl)-<2,7-dibrom-fluorenyliden-(9)>-phosphoran

Benzophenon-p-anisyl-diphenyl-phosphazin

diphenyl(p-tolyl)phosphine sulfide

Refernces

• 1、 García-Domínguez, Andrés,Gonzalez, Jorge A.,Leach, Andrew G.,Lloyd-Jones, Guy C.,Nichol, Gary S.,Taylor, Nicholas P.. "A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics". . . Retrieved 2022/01/04.
• 2、 Chen, Jin,Dai, Bencai,Liu, Changchun,Shen, Zhihao,Zhou, Yang. "Efficient potassium hydroxide promoted P-arylation of aryl halides with diphenylphosphine". . . Retrieved 2021/06/26.