1-Methoxy-2-naphthoic acid

Base Information

• Chemical Name: 1-Methoxy-2-naphthoic acid
• CAS No.: 883-21-6
• Molecular Formula: C12H10 O3
• Molecular Weight: 202.21
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID30346009
• Nikkaji Number: J1.046.217G
• Wikidata: Q82118852
• Mol file: 883-21-6.mol

Synonyms:1-Methoxy-2-naphthoic acid;883-21-6;1-methoxynaphthalene-2-carboxylic acid;1-METHOXY-2-NAPHTHOICACID;1-Methoxy-naphthoic acid;1-Methoxy-2-naphthoic acid #;SCHEMBL1671110;DTXSID30346009;1-Methoxy-2-naphthoic acid, 97%;MFCD00094169;AKOS009076136;1-methoxy-2-naphthalene carboxylic acid;1-methoxy-naphthalene-2-carboxylic acid;LS-08565;CS-0204700;FT-0633076;E78135

Chemical Property of 1-Methoxy-2-naphthoic acid

Chemical Property:

• Vapor Pressure: 9.02E-06mmHg at 25°C
• Melting Point: 125-129 °C(lit.)
• Refractive Index: 1.64
• Boiling Point: 358.8°C at 760 mmHg
• PKA: 4.09±0.30(Predicted)
• Flash Point: 142.1°C
• PSA: 46.53000
• Density: 1.263g/cm³
• LogP: 2.54660
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 239

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methoxy-2-naphthoic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC2=CC=CC=C21)C(=O)O
• Uses: 1-Methoxy-2-naphthoic acid may be used in the synthesis of 2-(1-methoxy-2-naphthyl)-4,4-dimethyl-2-oxazoline. It may also be used in the synthesis of the following compounds:1-sec-butyl-2-naphthoic acid1-tert-butyl-2-naphthoic acid1-ethyl-2-naphthoic acid1-vinyl-2-naphthoic acid 1-phenyl-2-naphthoic acid1-(2,5-dimethylphenyl)-2-naphthoic acid2′-methoxy-[1,1′-binaphthalene]-2-carboxylic acid

Technology Process of 1-Methoxy-2-naphthoic acid

There total 3 articles about 1-Methoxy-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-methoxy-2-naphthaldehyde tosylhydrazone → (3-oxo-1,3-dihydroisobenzofuran-1-yl)acetic acid (4743-58-2) + (E)-o-carboxycinnamic acid (18454-53-0) + 1-methoxy-2-naphthoic acid (883-21-6)

Guidance literature:

With poly(bis-1,2-diphenylene) diselenide; dihydrogen peroxide; In tetrahydrofuran; water; for 20h; Heating;

Reference yield: 48.0%

1-methoxy-2-naphthaldehyde (50493-10-2) → (3-oxo-1,3-dihydroisobenzofuran-1-yl)acetic acid (4743-58-2) + (E)-o-carboxycinnamic acid (18454-53-0) + 1-methoxy-2-naphthoic acid (883-21-6)

Guidance literature:

With poly(bis-1,2-diphenylene) diselenide; dihydrogen peroxide; In tetrahydrofuran; water; for 20h; Heating;

Reference yield:

1-(1-methoxy-2-naphthoyloxy)-2-pyridone (390755-09-6) → 2-Pyridone (142-08-5,1199357-22-6) + 1-methoxy-2-naphthoic acid (883-21-6)

Guidance literature:

In acetonitrile; at 20 ℃; UV-irradiation;

DOI:10.1246/bcsj.76.575

upstream raw materials:

1-(1-methoxy-2-naphthoyloxy)-2-pyridone

1-methoxy-2-naphthaldehyde

Downstream raw materials:

2-methyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

1,2,3,4-tetrahydro-2-naphthoic acid

rac-(S)-2-methyl-1,2-dihydronaphthalene-2-carboxylic acid

naphthalene-2-carboxylate

Refernces

• 1、 Najiwara, Toshihiro,Hashimoto, Ji-ichiro,Segawa, Katsunori,Sakuragi, Hirochika. "Behavior of naphthoyloxyl and methoxynaphthoyloxyl radicals generated from the photocleavage of dinaphthoyl peroxides and 1-(naphthoyloxy)-2-pyridones". . p. 575 - 585. Retrieved 2007/10/03.