3-(METHYLAMINO)ACRYLOPHENONE

Base Information

• Chemical Name: 3-(METHYLAMINO)ACRYLOPHENONE
• CAS No.: 877-50-9
• Molecular Formula: C10H11 N O
• Molecular Weight: 161.203
• Mol file: 877-50-9.mol

Synonyms:Acrylophenone,3-(methylamino)- (7CI,8CI)

Chemical Property of 3-(METHYLAMINO)ACRYLOPHENONE

Chemical Property:

• PSA: 29.10000
• LogP: 1.99330

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(METHYLAMINO)ACRYLOPHENONE

There total 6 articles about 3-(METHYLAMINO)ACRYLOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzoylacetaldehyde sodium salt + methylamine hydrochloride (593-51-1) → 3-(methylamino)-1-phenylprop-2-en-1-one (877-50-9)

Guidance literature:

Reference yield:

1-phenyl-3-dimethylaminoprop-2-enone (1201-93-0) + methylamine (74-89-5) → 3-(methylamino)-1-phenylprop-2-en-1-one (877-50-9)

Guidance literature:

With potassium hydrogensulfate; In water; at 50 ℃;

DOI:10.1007/s00044-015-1332-x

Reference yield:

acetophenone (98-86-2) → 3-(methylamino)-1-phenylprop-2-en-1-one (877-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Microwave irradiation

2: potassium hydrogensulfate / water / 50 °C

With potassium hydrogensulfate; In water;

DOI:10.1007/s00044-015-1332-x

upstream raw materials:

phenyl propargyl ketone

methylamine

methylamine hydrochloride

acetophenone

Downstream raw materials:

3-methylamino-1-phenylpropan-1-ol

(R)-N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Refernces

• 1、 -. "Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor". Page 4. . Retrieved 2010/02/07.