ethyl 1-{[(2,4-dichlorophenyl)acetyl]oxy}cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 1-{[(2,4-dichlorophenyl)acetyl]oxy}cyclohexanecarboxylate
• CAS No.: 361366-16-7
• Molecular Formula: C₁₇H₂₀Cl₂O₄
• Molecular Weight: 359.249
• Mol file: 361366-16-7.mol

Synonyms:1-[2-(2,4-Dichloro-phenyl)-acetoxy]-cyclohexanecarboxylic acid ethyl ester

Chemical Property of ethyl 1-{[(2,4-dichlorophenyl)acetyl]oxy}cyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 1.31E-07mmHg at 25°C
• Density: 1.329 at 20℃

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-{[(2,4-dichlorophenyl)acetyl]oxy}cyclohexanecarboxylate

There total 7 articles about ethyl 1-{[(2,4-dichlorophenyl)acetyl]oxy}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1-hydroxycyclohexanecarboxylate (1127-01-1) + 2,4-dichlorophenylacetyl chloride (53056-20-5) → 1-[2-(2,4-Dichloro-phenyl)-acetoxy]-cyclohexanecarboxylic acid ethyl ester (361366-16-7)

Guidance literature:

DOI:10.2533/000942903777678588

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-[2-(2,4-Dichloro-phenyl)-acetoxy]-cyclohexanecarboxylic acid ethyl ester (361366-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogen sulfate / water / 2.5 h / pH 3 - 4 / Cooling with ice

2: hydrogenchloride / water / 14 h / Cooling with ice

3: toluene / 12 h / Reflux

With hydrogenchloride; sodium hydrogen sulfate; In water; toluene;

Reference yield:

1-hydroxy-cyclohexanecarboxylic acid (1123-28-0) → 1-[2-(2,4-Dichloro-phenyl)-acetoxy]-cyclohexanecarboxylic acid ethyl ester (361366-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH

With toluene-4-sulfonic acid;

DOI:10.2533/000942903777678588

upstream raw materials:

ethyl 1-hydroxycyclohexanecarboxylate

2,4-dichlorophenylacetyl chloride

1-hydroxy-cyclohexanecarboxylic acid

2,4-dichlorophenylacetic acid

Downstream raw materials:

3-(2,4-dichlorophenyl)-4-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one

spirodiclofen

Refernces

• 1、 -. "NOVEL FORM OF SPIRODICLOFEN, A PROCESS FOR ITS PREPARATION AND USE THE SAME". Paragraph 0071; 0072. . Retrieved 2017/07/06.
• 2、 Bretschneider, Thomas,Benet-Buchholz, Jordi,Fischer, Reiner,Nauen, Ralf. "Spirodiclofen and spiromesifen - Novel acaricidal and insecticidal tetronic acid derivatives with a new mode of action". . p. 697 - 701. Retrieved 2007/10/03.