5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole

Base Information

• Chemical Name: 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole
• CAS No.: 1000029-31-1
• Molecular Formula: C₁₇H₁₂F₃NOS
• Molecular Weight: 335.35
• Mol file: 1000029-31-1.mol

Synonyms:5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole

Chemical Property of 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole

There total 3 articles about 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(4-(trifluoromethyl)phenyl)thiazole (119514-24-8) + para-iodoanisole (696-62-8) → 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole (1000029-31-1)

Guidance literature:

With triphenylphosphine; silver carbonate; [Pd((diphenylphosphanyl)ferrocene)Cl₂]*CH₂Cl₂; In water; at 60 ℃; for 24h;

DOI:10.1002/anie.200702141

Reference yield: 72.0%

4-Iodobenzotrifluoride (455-13-0) + 5-(4-methoxyphenyl)thioazole (68535-58-0) → 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole (1000029-31-1)

Guidance literature:

With [Pd(1,10-phenanthroline)₂](PF₆)₂; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 18h; regioselective reaction;

DOI:10.1039/c3sc52199k

Reference yield:

para-iodoanisole (696-62-8) → 5-(4-methoxyphenyl)-2-(4-trifluoromethylphenyl)thiazole (1000029-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt / 36 h / 80 °C

2: [Pd(1,10-phenanthroline)₂](PF₆)₂; caesium carbonate / N,N-dimethyl acetamide / 18 h / 150 °C

With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; [Pd(1,10-phenanthroline)₂](PF₆)₂; palladium diacetate; caesium carbonate; In N,N-dimethyl acetamide;

DOI:10.1039/c3sc52199k

upstream raw materials:

2-(4-(trifluoromethyl)phenyl)thiazole

para-iodoanisole

4-Iodobenzotrifluoride

5-(4-methoxyphenyl)thioazole

Refernces

• 1、 Turner, Gemma L.,Morris, James A.,Greaney, Michael F.. "Direct arylation of thiazoles on water". . p. 7996 - 8000. Retrieved 2008/09/17.