3-AMINOETHYLPYRIDINE HCL

Base Information

• Chemical Name: 3-AMINOETHYLPYRIDINE HCL
• CAS No.: 84359-16-0
• Molecular Formula: C7H10N2^.HCl
• Molecular Weight: 158.63
• Mol file: 84359-16-0.mol

Synonyms:3-Pyridineethanamine,monohydrochloride (9CI);

Chemical Property of 3-AMINOETHYLPYRIDINE HCL

Chemical Property:

• Vapor Pressure: 0.0719mmHg at 25°C
• Boiling Point: 228.8 °C at 760 mmHg
• Flash Point: 112.8 °C
• PSA: 38.91000
• LogP: 2.08510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Aminoethyl)pyridinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINOETHYLPYRIDINE HCL

There total 3 articles about 3-AMINOETHYLPYRIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-pyridin-3-ylethylamine (20173-24-4) → 2-(pyridin-3-yl)ethanamine hydrochloride (84359-16-0)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7cy01577a

Reference yield:

3-pyridinylacetonitrile (6443-85-2) → 3-Pyridineethanamine dihydrochloride (84359-16-0,90345-16-7)

Guidance literature:

With hydrogenchloride; ammonia; aluminum nickel; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

3-pyridinylacetonitrile (6443-85-2) → 2-(pyridin-3-yl)ethanamine hydrochloride (84359-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; ammonium hydroxide / isopropyl alcohol / 15 h / 120 °C / 37503.8 Torr / Autoclave

2: hydrogenchloride / methanol

With hydrogenchloride; ammonium hydroxide; hydrogen; In methanol; isopropyl alcohol;

DOI:10.1039/c7cy01577a

upstream raw materials:

2-pyridin-3-ylethylamine

3-pyridinylacetonitrile

Downstream raw materials:

1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)-N-(2-(pyridin-3-yl)ethyl)piperidine-4-carboxamide

C₂₁H₂₄N₂O₂

Refernces

• 1、 De Kloe, Gerdien E.,Retra, Kim,Geitmann, Matthis,K?llblad, Per,Nahar, Tariq,Van Elk, René,Smit, August B.,Van Muijlwijk-Koezen, Jacqueline E.,Leurs, Rob,Irth, Hubertus,Danielson, U. Helena,De Esch, Iwan J. P.. "Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (le hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands". experimental part. p. 7192 - 7201. Retrieved 2010/12/18.