3-Chloro-4-fluorophenylhydrazine

Base Information

• Chemical Name: 3-Chloro-4-fluorophenylhydrazine
• CAS No.: 84282-78-0
• Molecular Formula: C6H6 Cl F N2
• Molecular Weight: 160.578
• Hs Code.: 2928000090
• European Community (EC) Number: 624-856-5
• DSSTox Substance ID: DTXSID90371453
• Nikkaji Number: J2.503.265I
• Wikidata: Q82158788
• Mol file: 84282-78-0.mol

Synonyms:3-Chloro-4-fluorophenylhydrazine;84282-78-0;(3-chloro-4-fluorophenyl)hydrazine;Hydrazine, (3-chloro-4-fluorophenyl)-;MFCD00042214;1-(3-chloro-4-fluorophenyl)hydrazine;3-chloro-4-fluorophenyl hydrazine;SCHEMBL670295;DTXSID90371453;DUORBNTWCCJANU-UHFFFAOYSA-N;BBL104188;STL558008;(3-chloro-4-fluoro-phenyl)-hydrazine;AKOS005257997;3-Chloro-4-fluorophenylhydrazine, 96%;(3-chloranyl-4-fluoranyl-phenyl)diazane;MS-20196;FT-0615398;EN300-271049;A840752;J-512231

Chemical Property of 3-Chloro-4-fluorophenylhydrazine

Chemical Property:

• Vapor Pressure: 0.0187mmHg at 25°C
• Melting Point: 74-79 °C(lit.)
• Refractive Index: 1.624
• Boiling Point: 253.1°C at 760 mmHg
• PKA: 4.96±0.24(Predicted)
• Flash Point: 106.9°C
• PSA: 38.05000
• Density: 1.43g/cm³
• LogP: 2.53800
• Storage Temp.: Keep Cold
• Sensitive.: Air Sensitive
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.0203541
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-fluorophenylhydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NN)Cl)F

Technology Process of 3-Chloro-4-fluorophenylhydrazine

There total 2 articles about 3-Chloro-4-fluorophenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-chloro-4-fluorobenzenediazonium tetrafluoroborate → 3-chloro-4-fluorophenyl hydrazine (84282-78-0)

Guidance literature:

With borohydride exchange resin; In methanol; at 0 ℃;

DOI:10.1080/00397919708003336

Reference yield:

stannous chloride (2H2 O) + 3-chloro-4-fluorophenylamine (367-21-5) → 2-(3-chloro-4-fluorophenyl)-4,4-dimethylsemicarbazide (58038-06-5) + 3-chloro-4-fluorophenyl hydrazine (84282-78-0)

Guidance literature:

With sodium hydroxide; sodium nitrite; In hydrogenchloride; water;

Reference yield: 95.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 3-chloro-4-fluorophenyl hydrazine (84282-78-0) → Ethyl pyruvate 3-chloro-4-fluorophenylhydrazone (473258-19-4)

Guidance literature:

In ethanol; for 1h; Reflux;

upstream raw materials:

3-chloro-4-fluorophenylamine

Downstream raw materials:

2-(3-chloro-4-fluorophenyl)hydrazinecarboxylic acid ethyl ester

N'-(3-Chloro-4-fluoro-phenyl)-hydrazinecarboxylic acid phenyl ester

(3-chloro-4-fluoro-phenyl)-carbamic acid tert-butyl ester

1-(3-chloro-4-fluoro-phenylamino)-pyrrole-2,5-dione

Refernces

• 1、 -. "Preparation of 2-phenylsemicarbazides". . . Retrieved 2008/06/13.