1-(2,4-Dimethoxyphenyl)ethanol

Base Information

• Chemical Name: 1-(2,4-Dimethoxyphenyl)ethanol
• CAS No.: 829-19-6
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.219
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID00543326
• Nikkaji Number: J2.629.683H
• Mol file: 829-19-6.mol

Synonyms:1-(2,4-dimethoxyphenyl)ethanol;829-19-6;1-(2,4-dimethoxyphenyl)ethan-1-ol;SCHEMBL11709428;DTXSID00543326;RUANRSQPKRJMNZ-UHFFFAOYSA-N;1-(2,4-dimethoxy-phenyl)-ethanol;AKOS000249536;SB85149;CS-0274749;EN300-40885;3-(Benzyloxy)-6-bromo-2-fluorophenylboronicacid

Chemical Property of 1-(2,4-Dimethoxyphenyl)ethanol

Chemical Property:

• PSA: 38.69000
• LogP: 1.75710
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

99%min ^*data from raw suppliers

2,4-Dimethoxyphenylmethylcarbinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=C(C=C(C=C1)OC)OC)O

Technology Process of 1-(2,4-Dimethoxyphenyl)ethanol

There total 11 articles about 1-(2,4-Dimethoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dimethyl zinc(II) (544-97-8) + 2,4-Dimethoxybenzaldehyde (613-45-6) → (S)-1-(2,4-dimethoxyphenyl)ethan-1-ol (829-19-6)

Guidance literature:

dimethyl zinc(II); With C₄₁H₄₂N₂O₃; In hexane; toluene; at 0 - 40 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

2,4-Dimethoxybenzaldehyde; In hexane; toluene; at 0 - 30 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c7ob01717k

Reference yield: 99.0%

2',4'-dimethoxyacetophenone (829-20-9) → 1-(2,4-dimethoxyphenyl)ethan-1-ol (89691-57-6,829-19-6)

Guidance literature:

2',4'-dimethoxyacetophenone; With tetrabutylammonium tricarbonylnitrosylferrate; tricyclohexylphosphine; In 1,4-dioxane; at 50 ℃; Inert atmosphere;

With water; sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 1.5h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100717

Reference yield: 98.0%

2',4'-dimethoxyacetophenone (829-20-9) → (R)-1-(2,4-dimethoxyphenyl)ethanol (829-19-6)

Guidance literature:

With polymethylhydrosiloxane; copper(l) chloride; sodium t-butanolate; (R)-(-)-DTBM-SEGPHOS; In toluene; at -78 - 20 ℃; for 3h;

DOI:10.1021/ja021391f

upstream raw materials:

2',4'-dimethoxyacetophenone

methyl magnesium iodide

2,4-Dimethoxybenzaldehyde

1,3-Dimethoxybenzene

Downstream raw materials:

1-(1-azidoethyl)-2,4-dimethoxybenzene

2,4-dimethoxystyrene

Refernces

• 1、 Alharthi, Fahad A.,Alsalme, Ali,Dar, Bashir A.,Farooq, Saleem,Hamid, Abid,Hussain, Aashiq,Koul, S.. "Dihydropyrimidinones: Efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity". . p. 42221 - 42234. Retrieved 2020/12/09.
• 2、 Zhou, Gang,Aboo, Ahmed H.,Robertson, Craig M.,Liu, Ruixia,Li, Zhenhua,Luzyanin, Konstantin,Berry, Neil G.,Chen, Weiping,Xiao, Jianliang. "N,O- vs N,C-Chelation in Half-Sandwich Iridium Complexes: A Dramatic Effect on Enantioselectivity in Asymmetric Transfer Hydrogenation of Ketones". . p. 8020 - 8026. Retrieved 2018/09/06.