Pyrimidine, 2-(methylthio)- (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrimidine, 2-(methylthio)- (6CI,7CI,8CI,9CI)
• CAS No.: 823-09-6
• Molecular Formula: C5H6 N2 S
• Molecular Weight: 126.182
• Hs Code.: 29335990
• Mol file: 823-09-6.mol

Synonyms:2-(Methylthio)pyrimidine;2-Methylmercaptopyrimidine; 2-Methylsulfanylpyrimidine

Chemical Property of Pyrimidine, 2-(methylthio)- (6CI,7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.214mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 215.6ºC at 760 mmHg
• Flash Point: 84.2ºC
• PSA: 51.08000
• Density: 1.19g/cm3
• LogP: 1.19850

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methylthiopyrimidine ^*data from reagent suppliers

Safty Information:

• Statements: 36-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-(methylthio)- (6CI,7CI,8CI,9CI)

There total 19 articles about Pyrimidine, 2-(methylthio)- (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

S-Methylisothiourea sulfate (867-44-7,147895-43-0) + 2-bromopyrimidine (4595-60-2) → 2-(methylsulfanyl)pyrimidine (823-09-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 1h;

DOI:10.1039/c8ob01758a

Reference yield: 97.0%

2-cyanopyrimidine (14080-23-0) + 2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) → 2-(methylsulfanyl)pyrimidine (823-09-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 2h;

DOI:10.1002/ejoc.201901364

Reference yield: 92.0%

S-methylisothiourea hemisulphate (147895-43-0) + 2-bromopyrimidine (4595-60-2) → 2-(methylsulfanyl)pyrimidine (823-09-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 12h;

DOI:10.1002/anie.201910436

upstream raw materials:

2-thioxopyrimidine

dimethyl sulfate

4-Chloro-2-methylthiopyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine

Downstream raw materials:

N-(4-methoxybenzyl)pyrimidin-2-amine

2-(benzylamino)pyrimidine

Pyrimidin-2(1H)-one

5-bromo-2-methylthiopyrimidine

Refernces

• 1、 Thierry, Thibault,Pfund, Emmanuel,Lequeux, Thierry. "Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y". supporting information. p. 14826 - 14830. Retrieved 2021/10/01.
• 2、 Wei, Xiangyang,Zhang, Caiyang,Wang, Yifei,Zhan, Qi,Qiu, Guiying,Fan, Ling,Yin, Guodong. "Decyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines". . p. 7142 - 7150. Retrieved 2019/11/14.