Technology Process of methyl 2-(dibenzylamino)-3-(4-fluorophenyl)propanoate
There total 2 articles about methyl 2-(dibenzylamino)-3-(4-fluorophenyl)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-dibenzylaminopropionic acid methyl ester;
With
lithium dicyclohexylamide;
In
toluene;
at 0 ℃;
for 0.25h;
Inert atmosphere;
1-Bromo-4-fluorobenzene;
With
bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0); 2-(2-(dicyclohexylphosphino)-1H-imidazol-1-yl)-N,N-dimethylaniline;
In
toluene;
at 70 ℃;
for 16h;
Concentration;
Reagent/catalyst;
Temperature;
Time;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201206237
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 20 h / Inert atmosphere; Reflux
2.1: lithium dicyclohexylamide / toluene / 0.25 h / 0 °C / Inert atmosphere
2.2: 16 h / 70 °C / Inert atmosphere
With
sodium hydrogencarbonate; lithium dicyclohexylamide;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1002/anie.201206237
- Guidance literature:
-
methyl 2-(dibenzylamino)-3-(4-fluorophenyl)propanoate;
With
Pd(OH)2/C; hydrogen; acetic acid;
In
methanol; water;
at 20 ℃;
for 15h;
under 30003 Torr;
Autoclave;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
pH=8;
Inert atmosphere;
DOI:10.1002/anie.201206237
