Phenol, 4-bromo-2-ethyl-6-fluoro- (9CI)

Base Information

• Chemical Name: Phenol, 4-bromo-2-ethyl-6-fluoro- (9CI)
• CAS No.: 749929-49-5
• Molecular Formula: C8H8 Br F O
• Molecular Weight: 219.053
• Mol file: 749929-49-5.mol

Synonyms:4-Bromo-2-ethyl-6-fluorophenol

Chemical Property of Phenol, 4-bromo-2-ethyl-6-fluoro- (9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 2.85620

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-ethyl-6-fluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 4-bromo-2-ethyl-6-fluoro- (9CI)

There total 3 articles about Phenol, 4-bromo-2-ethyl-6-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-ethyl-6-fluorophenol (24539-97-7) → 4-bromo-2-ethyl-6-fluorophenol (749929-49-5)

Guidance literature:

With tetra-N-butylammonium tribromide; In chloroform; for 24h;

Reference yield:

3-fluorosalicylaldehyde (394-50-3) → 4-bromo-2-ethyl-6-fluorophenol (749929-49-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 2585.81 Torr

3: acetic acid; N-Bromosuccinimide / 1 h / 0 - 20 °C

With N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol;

Reference yield:

2-fluoro-6-(1-hydroxyethyl)phenol (749929-50-8) → 4-bromo-2-ethyl-6-fluorophenol (749929-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2585.81 Torr

2: acetic acid; N-Bromosuccinimide / 1 h / 0 - 20 °C

With N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; acetic acid; In methanol;

upstream raw materials:

2-ethyl-6-fluorophenol

3-fluorosalicylaldehyde

2-fluoro-6-(1-hydroxyethyl)phenol

Downstream raw materials:

acetic acid 4-bromo-2-ethyl-6-fluoro-phenyl ester

Refernces

• 1、 -. "INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME". Page 154. . Retrieved 2008/06/13.