1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride

Base Information

• Chemical Name: 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride
• CAS No.: 73360-17-5
• Molecular Formula: C₁₇H₂₂NO₄*Cl
• Molecular Weight: 339.819
• Mol file: 73360-17-5.mol

Synonyms:1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride

Chemical Property of 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride

There total 4 articles about 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloromethyl benzoate (5335-05-7) + 3-acetoxyquinuclidine (827-61-2,59653-40-6,59653-42-8,72353-53-8) → 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride (73360-17-5)

Guidance literature:

In acetonitrile; at 70 ℃;

DOI:10.1021/jm00179a018

Reference yield:

benzoyl chloride (98-88-4) → 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride (73360-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 h / 90 - 100 °C

2: 100 percent / acetonitrile / 70 °C

In acetonitrile;

DOI:10.1021/jm00179a018

Reference yield:

3-quinuclidinol (1619-34-7) → 1-(phenylacetoxy)-3-acetoxyquinuclidinium chloride (73360-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / 2 h / Heating

2: 100 percent / acetonitrile / 70 °C

In pyridine; acetonitrile;

DOI:10.1021/jm00179a018

upstream raw materials:

chloromethyl benzoate

3-acetoxyquinuclidine

benzoyl chloride

3-quinuclidinol

Refernces

• 1、 Vinogradova, N. D.,Kuznetsov, S. G.,Chigareva, S. M.. "QUATERNARY AMMONIUM SALTS WITH LABILE N(1+) - C BONDS AS DRUG PRECURSORS". . p. 604 - 609. Retrieved 2007/10/02.