4-chloro-3-nitroisopropylbenzene

Base Information

• Chemical Name: 4-chloro-3-nitroisopropylbenzene
• CAS No.: 76611-15-9
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.637
• Mol file: 76611-15-9.mol

Synonyms:4-chloro-3-nitroisopropylbenzene

Chemical Property of 4-chloro-3-nitroisopropylbenzene

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-3-nitroisopropylbenzene

There total 4 articles about 4-chloro-3-nitroisopropylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

1-chloro-4-isopropylbenzene (2621-46-7) → 4-chloro-3-nitroisopropylbenzene (76611-15-9) + 1-chloro-4-isopropyl-3-nitrobenzene (76611-16-0) + 4-chlorobenzonitrile (100-00-5)

Guidance literature:

With nitric acid; In sulfuric acid; at 25 ℃;

DOI:10.1039/P29800001606

Reference yield:

1-chloro-4-isopropylbenzene (2621-46-7) → 4-chloro-3-nitroisopropylbenzene (76611-15-9) + para-chloroacetophenone (99-91-2) + 1-chloro-4-isopropyl-3-nitrobenzene (76611-16-0) + 4-chlorobenzonitrile (100-00-5)

Guidance literature:

With nitric acid; 4-aminobenzene sulfonic acid; In sulfuric acid; at 25 ℃; Product distribution; Rate constant; various concentrations and molar ratios of HNO₃ and H₂SO₄;

DOI:10.1039/P29800001606

Reference yield:

4-Isopropylaniline (99-88-7) → 4-chloro-3-nitroisopropylbenzene (76611-15-9)

Guidance literature:

Multi-step reaction with 2 steps

2: 70.1 percent / HNO₃ / aq. H₂SO₄ / 25 °C

With nitric acid; In sulfuric acid;

DOI:10.1039/P29800001606

upstream raw materials:

1-chloro-4-isopropylbenzene

4-Isopropylaniline

Refernces

• 1、 Manglik, Ajay K.,Moodie, Roy B.,Schofield, Kenneth,Tobin, Geoffrey D.,Coombes, Robert G.,Hadjigeorgiou, Panicos. "Electrophilic aromatic substitution. Part 24. The nitration of isopropylbenzene, 2- and 4-isopropyltoluene, 1-chloro-4-isopropylbenzene, 4-isopropylanisole, and 2-bromotoluene: Nitrodeisopropylation". . p. 1606 - 1616. Retrieved 2007/10/02.