(4-chloro-benzyl)-trityl ether

Base Information

• Chemical Name: (4-chloro-benzyl)-trityl ether
• CAS No.: 39834-47-4
• Molecular Formula: C₂₆H₂₁ClO
• Molecular Weight: 384.905
• Mol file: 39834-47-4.mol

Synonyms:(4-chloro-benzyl)-trityl ether

Chemical Property of (4-chloro-benzyl)-trityl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chloro-benzyl)-trityl ether

There total 5 articles about (4-chloro-benzyl)-trityl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

triphenylmethyl alcohol (76-84-6) + para-Chlorobenzyl alcohol (873-76-7) → (4-chloro-benzyl)-trityl ether (39834-47-4)

Guidance literature:

With nanoporous MCM-41-SO₃H; In neat (no solvent); at 20 ℃; for 0.5h; Milling;

DOI:10.1016/j.crci.2014.01.003

Reference yield: 95.0%

trityl chloride (76-83-5) + para-Chlorobenzyl alcohol (873-76-7) → (4-chloro-benzyl)-trityl ether (39834-47-4)

Guidance literature:

With iron(III) chloride; 1-(n-butyl)-3-methylimidazolium triflate; at 20 ℃; for 1h; Ionic liquid;

DOI:10.1080/00397910902838888

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) → (4-chloro-benzyl)-trityl ether (39834-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; acetic acid / Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH

2: benzene; triethylamine

With potassium acetate; acetic acid; triethylamine; benzene;

DOI:10.1021/ja01642a025

upstream raw materials:

trityl chloride

para-Chlorobenzyl alcohol

1-Chloro-4-(chloromethyl)benzene

benzyl trityl ether

Downstream raw materials:

para-Chlorobenzyl alcohol

Refernces

• 1、 Sreedhar,Radhika,Neelima,Chowdary,Rao, M. V. Basaveswara. "FeCl3-catalyzed tritylation of alcohols in ionic liquids". experimental part. p. 3785 - 3795. Retrieved 2009/12/08.