2-methylindol-3-yl 2-nitrophenyl sulphide

Base Information

• Chemical Name: 2-methylindol-3-yl 2-nitrophenyl sulphide
• CAS No.: 16942-16-8
• Molecular Formula: C₁₅H₁₂N₂O₂S
• Molecular Weight: 284.338
• Mol file: 16942-16-8.mol

Synonyms:2-methylindol-3-yl 2-nitrophenyl sulphide

Chemical Property of 2-methylindol-3-yl 2-nitrophenyl sulphide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-methylindol-3-yl 2-nitrophenyl sulphide

There total 4 articles about 2-methylindol-3-yl 2-nitrophenyl sulphide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methyl-1H-indole (95-20-5) + 2-nitrobenzenesulfenyl chloride (7669-54-7) → 2-methylindol-3-yl 2-nitrophenyl sulphide (16942-16-8)

Guidance literature:

With pyridine; In diethyl ether; at 25 ℃; for 0.333333h;

Reference yield: 86.0%

2-methyl-1H-indole (95-20-5) + C10H12Cl2N2O4PS(1+)*Cl(1-) → 2-methylindol-3-yl 2-nitrophenyl sulphide (16942-16-8)

Guidance literature:

2-methyl-1H-indole; C₁₀H₁₂Cl₂N₂O₄PS⁽¹⁺⁾*Cl^(1-); In dichloromethane; at 20 ℃; for 0.166667h;

With trichlorophosphate; In dichloromethane; for 4h;

DOI:10.1007/s10593-010-0629-4

Reference yield:

bis(2-nitrophenyl)disulfide (1155-00-6) → 2-methylindol-3-yl 2-nitrophenyl sulphide (16942-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂, I₂ / CCl₄ / 0.33 h / 35 °C

2: 96 percent / pyridine / diethyl ether / 0.33 h / 25 °C

With pyridine; iodine; chlorine; In tetrachloromethane; diethyl ether;

upstream raw materials:

2-methyl-1H-indole

2-nitrobenzenesulfenyl chloride

bis(2-nitrophenyl)disulfide

4-[(2-nitrophenyl)sulfanyl]morpholine

Downstream raw materials:

2-methylindol-3-yl 2-aminophenyl sulphide

Refernces

• 1、 Jackson, Anthony N.,Johnston, David K.,Shannon, Patrick V. R.. "Electrophilic Substitution in Indoles. Part 16. The Formation of Indolobenzothiazines and Indolobenzothiazepines in Intramolecular Cyclisation of (o-Nitrophenylthio)indoles". . p. 2017 - 2063. Retrieved 2007/10/02.