Technology Process of 9-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-2,3,5,7-tetrahydro-6H-pyrazolo[3,4-h]pyrrolo[4,3,2-de]quinolin-6-one
There total 15 articles about 9-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-2,3,5,7-tetrahydro-6H-pyrazolo[3,4-h]pyrrolo[4,3,2-de]quinolin-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-7-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indazol-5-yl}ethyl)carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
4 A molecular sieve; sodium hydrogencarbonate;
In
ethanol;
for 1.5h;
Heating;
DOI:10.1021/jm051247f
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: POCl3 / 1.5 h / 0 °C
2.1: ammonium acetate; acetic acid / 3 h / Heating
3.1: KOH / tetrahydrofuran / 0.08 h / 0 °C
3.2: 54 percent / tetrahydrofuran / 1 h / 20 °C
4.1: LiAlH4 / diethyl ether; CH2Cl2 / 0.25 h / 0 °C
5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C
5.2: 200 mg / tetrahydrofuran / 1 h / 20 °C
6.1: CAN / acetonitrile; H2O / 0.25 h / 20 °C
7.1: tetrahydrofuran; diethyl ether / 1 h
8.1: TFA / CH2Cl2 / 0.5 h / 20 °C
8.2: 4 Angstroem molecular sieve; NaHCO3 / ethanol / 1.5 h / Heating
With
ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium hydride; acetic acid; trifluoroacetic acid; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm051247f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; diethyl ether / 1 h
2.1: TFA / CH2Cl2 / 0.5 h / 20 °C
2.2: 4 Angstroem molecular sieve; NaHCO3 / ethanol / 1.5 h / Heating
With
trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm051247f