Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI)

Base Information

• Chemical Name: Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI)
• CAS No.: 748126-76-3
• Molecular Formula: C₁₀H₁₂FN
• Molecular Weight: 165.21
• Mol file: 748126-76-3.mol

Synonyms:Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI)

Chemical Property of Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI)

There total 18 articles about Cyclopropanemethanamine, 2-fluoro-2-phenyl-, (1R,2S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H14FNO2 → C10H12FN (748126-76-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2019.111626

Reference yield:

2-[(2-fluoro-2-phenylcyclopropyl)methyl]isoindoline-1,3-dione → trans-(2-fluoro-2-phenylcyclopropyl)methylamine (748126-76-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2019.111626

Reference yield:

cis-2-fluoro-2-phenylcyclopropanecarboxylic acid chloride → cis-(2-fluoro-2-phenylcyclopropyl)methylamine (748126-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.41 g / aq. NH₃ / dioxane / 1 h / 0 - 20 °C

2: BH₃*THF / Heating

With ammonium hydroxide; borane-THF; In 1,4-dioxane;

DOI:10.1021/jm030398k

upstream raw materials:

α-fluorostyrene

(2-bromo-1-fluoroethyl)benzene

styrene

Refernces

• 1、 Yoshida, Shinichi,Meyer, Oliver G. J.,Rosen, Thomas C.,Haufe, Günter,Ye, Song,Sloan, Milton J.,Kirk, Kenneth L.. "Fluorinated Phenylcyclopropylamines. 1. Synthesis and Effect of Fluorine Substitution at the Cyclopropane Ring on Inhibition of Microbial Tyramine Oxidase". . p. 1796 - 1806. Retrieved 2007/10/03.