(S)-3-Ethylmorpholine

Base Information

• Chemical Name: (S)-3-Ethylmorpholine
• CAS No.: 748117-01-3
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Hs Code.: 2934999090
• Mol file: 748117-01-3.mol

Synonyms:(S)-3-Ethylmorpholine;

Chemical Property of (S)-3-Ethylmorpholine

Chemical Property:

• Vapor Pressure: 2.36mmHg at 25°C
• Refractive Index: 1.413
• Boiling Point: 160.6 °C at 760 mmHg
• Flash Point: 54.2 °C
• PSA: 21.26000
• Density: 0.878 g/cm³
• LogP: 0.71360

Purity/Quality:

99% ^*data from raw suppliers

(3S)-3-Ethylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Ethylmorpholine

There total 3 articles about (S)-3-Ethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-5-ethylmorpholin-3-one (1007112-54-0) → (S)-3-ethylmorpholine (748117-01-3)

Guidance literature:

(S)-5-ethylmorpholin-3-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 20.3333h; Heating / reflux;

With water; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

(S)-4-(benzo[d]thiazol-2-ylsulfonyl)-3-ethylmorpholine → (S)-3-ethylmorpholine (748117-01-3)

Guidance literature:

With lithium hydroxide monohydrate; mercaptoacetic acid; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/jo101339g

Reference yield:

2-chloro-N-[(2S)-1-hydroxybutan-2-yl]acetamide (1239568-72-9) → (S)-3-ethylmorpholine (748117-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1055/s-0034-1379641

upstream raw materials:

(S)-5-ethylmorpholin-3-one

2-chloro-N-[(2S)-1-hydroxybutan-2-yl]acetamide

Downstream raw materials:

(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl)urea

(S)-1-ethyl-3-(4-(6-(3-ethylmorpholino)-7-methyl-7H-purin-2-yl)phenyl)urea

Refernces

• 1、 Bornholdt, Jan,Felding, Jakob,Kristensen, Jesper Langgaard. "Synthesis of enantiopure 3-substituted morpholines". supporting information; experimental part. p. 7454 - 7457. Retrieved 2011/01/04.