3-(p-chlorophenyl)-4,4-diethoxybutanenitrile

Base Information

• Chemical Name: 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile
• CAS No.: 233760-10-6
• Molecular Formula: C₁₂H₁₂ClNO₂
• Molecular Weight: 237.686
• Mol file: 233760-10-6.mol

Synonyms:3-(p-chlorophenyl)-4,4-diethoxybutanenitrile

Chemical Property of 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile

There total 2 articles about 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-bromomethyl-1,3-dioxolane (4360-63-8) + p-chlorobenzyl cyanide (140-53-4) → 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile (233760-10-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil;

Reference yield:

2-(4-chloro-phenyl)-3-[1,3]dioxolan-2-yl-propionaldehyde oxime → 3-(p-chlorophenyl)-4,4-diethoxybutanenitrile (233760-10-6)

Guidance literature:

With carbon disulfide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; at 20 ℃; for 0.5h;

Reference yield: 85.0%

3-(p-chlorophenyl)-4,4-diethoxybutanenitrile (233760-10-6) + acetylene (74-86-2,25067-58-7) → 2-[1-(4-chloro-phenyl)-2-[1,3]dioxolan-2-yl-ethyl]-pyridine (233760-12-8)

Guidance literature:

With (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene; at 120 ℃; for 72h; under 9500 Torr;

upstream raw materials:

2-bromomethyl-1,3-dioxolane

p-chlorobenzyl cyanide

Downstream raw materials:

2-[1-(4-chloro-phenyl)-2-[1,3]dioxolan-2-yl-ethyl]-pyridine

3-(p-chlorophenyl)-3-(2-pyridyl)propanal

Chlorpheniramine

Refernces

• 1、 Marchetti, Mauro,Sechi, Barbara,Azzena, Ugo,Botteghi, Carlo,Paganelli, Stefano,Ponte, Gino Del,Stefani, Helio A.. "New synthetic route to N,N-disubstituted 3-aryl-3-pyridylpropylamines: Pheniramines from 3-aryl-3-(2-pyridyl)propanals". . p. 219 - 225. Retrieved 2007/10/03.