Technology Process of benzyl N-(2-azidoethyl)-N-[2-N-(benzhydryloxycarbonyl)guanine-9-acetyl]glycinate
There total 6 articles about benzyl N-(2-azidoethyl)-N-[2-N-(benzhydryloxycarbonyl)guanine-9-acetyl]glycinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
N,N-dimethyl-formamide;
at 23 ℃;
for 2h;
DOI:10.1021/ol0358408
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C
1.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C
2.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C
3.1: 49 percent / TOTU; triethylamine / dimethylformamide / 2 h / 23 °C
With
O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-Hydroxypropionitrile;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol0358408
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 67.7 percent / potassium carbonate / dimethylformamide / 0 - 20 °C
2.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C
2.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C
3.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C
4.1: 49 percent / TOTU; triethylamine / dimethylformamide / 2 h / 23 °C
With
O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-Hydroxypropionitrile;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol0358408