Technology Process of 2-hydroxy-8-phenyloctanenitrile
There total 2 articles about 2-hydroxy-8-phenyloctanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-phenylheptan-1-ol;
With
sodium hypochlorite; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; sodium hydrogencarbonate; sodium bromide;
In
water; ethyl acetate; toluene;
at -5 ℃;
With
sodium hydrogensulfite;
In
dichloromethane; water;
at 20 ℃;
for 0.5h;
potassium cyanide;
In
water;
at 0 - 20 ℃;
DOI:10.1016/j.bmc.2008.10.046
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Cooling with ice
2: ethyl acetate; water / 24 h / 20 °C
With
Dess-Martin periodane;
In
dichloromethane; water; ethyl acetate;
- Guidance literature:
-
2-hydroxy-8-phenyloctanenitrile;
With
acetyl chloride;
In
ethanol; chloroform;
at 0 - 20 ℃;
for 2.5h;
Inert atmosphere;
2-amino-3-hydroxypyridine;
With
pyridine;
In
ethanol;
at 80 ℃;
for 8h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/acs.jmedchem.5b01627
