6-Aminopyridine-2-sulfonamide

Base Information

• Chemical Name: 6-Aminopyridine-2-sulfonamide
• CAS No.: 75903-58-1
• Molecular Formula: C5H7 N3 O2 S
• Molecular Weight: 173.195
• European Community (EC) Number: 811-766-8
• DSSTox Substance ID: DTXSID201308409
• Mol file: 75903-58-1.mol

Synonyms:6-Aminopyridine-2-sulfonamide;75903-58-1;2-Pyridinesulfonamide,6-amino-(9CI);6-Amino-2-pyridinesulfonamide;SCHEMBL17647899;GFQVENVAWVSTNP-UHFFFAOYSA-N;DTXSID201308409;GS1214;MFCD18816592;AKOS022638672;DS-8691;SB53445;CS-0158099;C76427;EN300-276714;A923258

Chemical Property of 6-Aminopyridine-2-sulfonamide

Chemical Property:

• PSA: 107.45000
• LogP: 1.67350
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 173.02589765
• Heavy Atom Count: 11
• Complexity: 220

Purity/Quality:

99%, ^*data from raw suppliers

6-Aminopyridine-2-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)S(=O)(=O)N)N

Technology Process of 6-Aminopyridine-2-sulfonamide

There total 1 articles about 6-Aminopyridine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.7%

2-sulfamoylpyridine-6-carboxyazide (75903-56-9) → 6-aminopyridine-2-sulfonamide (75903-58-1)

Guidance literature:

With acetic acid; at 95 ℃; for 1h;

DOI:10.1021/jm00186a017

Reference yield: 81.0%

4-bromo-2,3-difluoro-benzoic acid (194804-91-6) + 6-aminopyridine-2-sulfonamide (75903-58-1) → N-[(6-amino-2-pyridyl)sulfonyl]-4-bromo-2,3-difluoro-benzamide

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 60 ℃; for 4h; Sealed tube;

Reference yield: 79.0%

2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid (82671-06-5) + 6-aminopyridine-2-sulfonamide (75903-58-1) → N-[(6-amino-2-pyridyl)sulfonyl]-2,6-dichloro-5-fluoro-pyridine-3-carboxamide

Guidance literature:

2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 60 ℃; for 0.833333h;

6-aminopyridine-2-sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

2-sulfamoylpyridine-6-carboxyazide

Refernces