Solifenacin Related CoMpound 4 Succinate

Base Information

• Chemical Name: Solifenacin Related CoMpound 4 Succinate
• CAS No.: 862207-71-4
• Molecular Formula: C₄H₆O₄*C₂₃H₂₆N₂O₂
• Molecular Weight: 480.561
• Mol file: 862207-71-4.mol

Synonyms:(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate

Chemical Property of Solifenacin Related CoMpound 4 Succinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(1S,3’S)-SolifenacinSuccinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (1S,3’S)-Solifenacin Succinate is a muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence.

Technology Process of Solifenacin Related CoMpound 4 Succinate

There total 5 articles about Solifenacin Related CoMpound 4 Succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester (732228-02-3,180272-14-4) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (740780-79-4,180272-14-4) + succinic acid (110-15-6) + (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (22990-19-8,96719-89-0,118864-75-8) + solifenacin (242478-37-1,180272-14-4) → (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate (862207-71-4,1262506-09-1,242478-38-2) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate (862207-70-3,1262506-09-1,242478-38-2) + 1-(S)-phenyl-1,2,3,4-tetrahydroisoquinoline succinate + solifenacin succinate (1262506-09-1,242478-38-2)

Guidance literature:

In isopropyl alcohol; at 20 ℃;

Reference yield:

succinic acid (110-15-6) + solifenacin (242478-37-1,180272-14-4) → (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate (862207-71-4,1262506-09-1,242478-38-2) + solifenacin succinate (1262506-09-1,242478-38-2)

Guidance literature:

In ethyl acetate; at 25 - 80 ℃; for 10h;

Reference yield:

succinic acid (110-15-6) + solifenacin (242478-37-1,180272-14-4) → (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate (862207-71-4,1262506-09-1,242478-38-2) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate (862207-70-3,1262506-09-1,242478-38-2) + solifenacin succinate (1262506-09-1,242478-38-2)

Guidance literature:

In ethanol; ethyl acetate; at 0 - 50 ℃; Product distribution / selectivity;

upstream raw materials:

succinic acid

solifenacin

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

Refernces

• 1、 -. "NOVEL PROCESS FOR THE PREPARATION OF SOLIFENACIN SUCCINATE". Page/Page column 10. . Retrieved 2012/01/14.
• 2、 -. "COMPOSITION CONTAINING SOLIFENACIN SUCCINATE". Page/Page column 11. . Retrieved 2008/06/13.