C₂₇H₄₆O₄

Base Information

• Chemical Name: C₂₇H₄₆O₄
• CAS No.: 1446749-30-9
• Molecular Formula: C₂₇H₄₆O₄
• Molecular Weight: 434.66
• Mol file: 1446749-30-9.mol

Synonyms:C₂₇H₄₆O₄

Chemical Property of C₂₇H₄₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₄₆O₄

There total 3 articles about C₂₇H₄₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

isomargaric acid (1603-03-8) + (2S)-3-(benzyloxy)propane-1,2-diol (17325-85-8) → C27H46O4 (1446749-30-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 13h; regioselective reaction;

DOI:10.1002/chem.201204550

Reference yield:

benzyl bromide (100-39-0) → C27H46O4 (1446749-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane; water

3: dmap; dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 13 h / 0 - 20 °C

With dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201204550

Reference yield:

(R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane (14347-83-2) → C27H46O4 (1446749-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane; water

2: dmap; dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 13 h / 0 - 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201204550

upstream raw materials:

benzyl bromide

isomargaric acid

(2S)-3-(benzyloxy)propane-1,2-diol

(R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane

Downstream raw materials:

C₄₂H₇₄O₅

Refernces