Technology Process of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine
There total 5 articles about (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd; (R)-8-chloro-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine;
With
acetic acid;
In
methanol;
at 20 ℃;
for 0.5h;
With
sodium cyanoborohydride;
In
methanol;
for 1h;
With
water; sodium hydrogencarbonate;
In
methanol;
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Inert atmosphere;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; mineral oil; methanol / 0 - 50 °C
3.1: acetic acid / methanol / 0.5 h / 20 °C
3.2: 1 h
With
sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; mineral oil;