4-ethoxyphenyl benzyl ether

Base Information

• Chemical Name: 4-ethoxyphenyl benzyl ether
• CAS No.: 69697-44-5
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 69697-44-5.mol

Synonyms:4-ethoxyphenyl benzyl ether

Chemical Property of 4-ethoxyphenyl benzyl ether

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethoxyphenyl benzyl ether

There total 1 articles about 4-ethoxyphenyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

ethyl bromide (74-96-4) + 4-Benzyloxyphenol (103-16-2) → 4-ethoxyphenyl benzyl ether (69697-44-5)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 48h; Heating;

DOI:10.1016/S0223-5234(99)00114-2

Reference yield: 87.0%

4-ethoxyphenyl benzyl ether (69697-44-5) → 4-Ethoxyphenol (622-62-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr;

DOI:10.1016/S0223-5234(99)00114-2

Reference yield:

4-ethoxyphenyl benzyl ether (69697-44-5) → 2-((4-ethyoxyphenoxy)methyl)oxirane (18110-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C / 760 Torr

2: KOH / ethanol / 20 °C

With potassium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; 1: Hydrogenolysis / 2: Etherification;

DOI:10.1016/S0223-5234(99)00114-2

upstream raw materials:

ethyl bromide

4-Benzyloxyphenol

Downstream raw materials:

4-Ethoxyphenol

2-((4-ethyoxyphenoxy)methyl)oxirane

Refernces

• 1、 Louis, Simon N.,Nero, Tracy L.,Iakovidis, Dimitri,Colagrande, Felicia M.,Jackman, Graham P.,Louis, William J.. "β1- and β2-adrenoceptor antagonist activity of a series of para- substituted N-isopropylphenoxypropanolamines". . p. 919 - 937. Retrieved 2007/10/03.