cyclohexyl methoxymethyl ketone

Base Information

• Chemical Name: cyclohexyl methoxymethyl ketone
• CAS No.: 58435-70-4
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.225
• Mol file: 58435-70-4.mol

Synonyms:cyclohexyl methoxymethyl ketone

Chemical Property of cyclohexyl methoxymethyl ketone

Chemical Property:

Purity/Quality:

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Technology Process of cyclohexyl methoxymethyl ketone

There total 3 articles about cyclohexyl methoxymethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methoxy-N-methylcyclohexanecarboxamide (80783-98-8) + chloromethyl methyl ether (107-30-2) → cyclohexyl methoxymethyl ketone (58435-70-4)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; mineral oil; at -78 ℃; for 2.5h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6cc03532a

Reference yield:

2-methoxyacetonitrile (1738-36-9) + cyclohexylmagnesiumchloride (931-51-1) → cyclohexyl methoxymethyl ketone (58435-70-4)

Guidance literature:

With diethyl ether; Eintragen des Reaktionsgemisches in Eis und Schwefelsaeure;

DOI:10.1021/jo01202a010

Reference yield:

(methoxymethyl)trimethylsilane (14704-14-4) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → cyclohexyl methoxymethyl ketone (58435-70-4)

Guidance literature:

Multistep reaction; (i) sBuLi, (ii) /BRN= 385735/, (iii) pyridine chlorochromate;

DOI:10.1039/c39790000822

upstream raw materials:

2-methoxyacetonitrile

cyclohexylmagnesiumchloride

(methoxymethyl)trimethylsilane

cyclohexanone

Refernces