4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

Base Information

• Chemical Name: 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester
• CAS No.: 198410-26-3
• Molecular Formula: C₂₀H₂₀FN₃O₈S
• Molecular Weight: 481.459
• Mol file: 198410-26-3.mol

Synonyms:4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

Chemical Property of 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester

There total 5 articles about 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester (198410-26-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-diisopropylethylamine

2.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran

3.1: NaHCO₃

4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

5.1: Et₃N

With n-butyllithium; ammonium formate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;

DOI:10.1016/S0960-894X(02)00043-4

Reference yield:

3-fluoro-4-(4-morpholinyl)nitrobenzene (2689-39-6) → 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester (198410-26-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran

2.1: NaHCO₃

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: hexane; tetrahydrofuran / -78 - 20 °C

4.1: Et₃N

With n-butyllithium; ammonium formate; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;

DOI:10.1016/S0960-894X(02)00043-4

Reference yield:

3-fluoro-4-(morpholinyl)aniline (93246-53-8) → 4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester (198410-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaHCO₃

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: hexane; tetrahydrofuran / -78 - 20 °C

3.1: Et₃N

With n-butyllithium; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1016/S0960-894X(02)00043-4

upstream raw materials:

4-Nitrobenzenesulfonyl chloride

(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol

3,4-difluoronitrobenzene

3-fluoro-4-(4-morpholinyl)nitrobenzene

Downstream raw materials:

linezolid

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

Refernces