Cyclopentanol, 1-(trifluoromethyl)- (9CI)

Base Information

• Chemical Name: Cyclopentanol, 1-(trifluoromethyl)- (9CI)
• CAS No.: 737765-57-0
• Molecular Formula: C6H9 F3 O
• Molecular Weight: 154.1302696
• Hs Code.: 2906199090
• Mol file: 737765-57-0.mol

Synonyms:Cyclopentanol, 1-(trifluoromethyl)- (9CI)

Chemical Property of Cyclopentanol, 1-(trifluoromethyl)- (9CI)

Chemical Property:

• Boiling Point: 127.5±35.0 °C(Predicted)
• PKA: 12.60±0.20(Predicted)
• PSA: 20.23000
• Density: 1.315±0.06 g/cm3(Predicted)
• LogP: 1.85380

Purity/Quality:

99% ^*data from raw suppliers

1-(trifluoromethyl)cyclopentan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanol, 1-(trifluoromethyl)- (9CI)

There total 1 articles about Cyclopentanol, 1-(trifluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(trifluoromethyl)trimethylsilane (81290-20-2) + cyclopentanone (120-92-3) → 1-(trifluoromethyl)cyclopentan-1-ol (737765-57-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield: 87.0%

1-(trifluoromethyl)cyclopentan-1-ol (737765-57-0) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl (1-(trifluoromethyl)cyclopentyl) carbonate

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00554

Reference yield:

1-(trifluoromethyl)cyclopentan-1-ol (737765-57-0) + toluene-4-sulfonic acid (104-15-4) + 1,1'-carbonyldiimidazole (530-62-1) → C10H11F3N2O2*C7H8O3S

Guidance literature:

1-(trifluoromethyl)cyclopentanol; 1,1'-carbonyldiimidazole; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

toluene-4-sulfonic acid; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c7ob00378a

upstream raw materials:

(trifluoromethyl)trimethylsilane

cyclopentanone

Refernces

• 1、 -. "MODULATORS OF GPR119 AND THE TREATMENT OF DISORDERS RELATED THERETO". Page/Page column 95; 96. . Retrieved 2014/05/24.