2-[phenyl(2-pyridinyl)methyl]pyridine

Base Information

• Chemical Name: 2-[phenyl(2-pyridinyl)methyl]pyridine
• CAS No.: 79057-57-1
• Molecular Formula: C₁₇H₁₄N₂
• Molecular Weight: 246.312
• Mol file: 79057-57-1.mol

Synonyms:α,α-bis(pyridin-2-yl)toluene

Chemical Property of 2-[phenyl(2-pyridinyl)methyl]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[phenyl(2-pyridinyl)methyl]pyridine

There total 8 articles about 2-[phenyl(2-pyridinyl)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-pyridine (109-04-6) + 2-Benzylpyridine (101-82-6) → α,α-bis(pyridin-2-yl)toluene (79057-57-1)

Guidance literature:

With 1,1,4,7,10,10-hexamethyltriethylenetetramine; NiXantphos; palladium diacetate; sodium hexamethyldisilazane; at 23 ℃; for 12h; Reagent/catalyst; Catalytic behavior; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1039/c2sc21673f

Reference yield: 91.0%

bis(2-pyridyl)methane (1132-37-2) + chlorobenzene (108-90-7) → α,α-bis(pyridin-2-yl)toluene (79057-57-1)

Guidance literature:

With cesium hydroxide; tricyclohexylphosphine; di(acetonitrile)dichloropalladium; In toluene; xylene; for 6h; Heating;

DOI:10.1021/ol0708119

Reference yield: 86.0%

2-Benzylpyridine (101-82-6) + 2-fluoropyridine (372-48-5) → α,α-bis(pyridin-2-yl)toluene (79057-57-1)

Guidance literature:

2-Benzylpyridine; With lithium diisopropyl amide; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

2-fluoropyridine; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02602

upstream raw materials:

phenylbis(pyridine-2-yl)methanol

phenyl-di-[2]pyridyl-acetonitrile

2-bromo-pyridine

2-Benzylpyridine

Downstream raw materials:

phenylbis(pyridine-2-yl)methanol

(bis(2-pyridyl)phenylmethane)methylmercury(II) nitrate

K⁽¹⁺⁾*C₆H₅C(C₅H₄N)2^(1-)=KC₆H₅C(C₅H₄N)2

Refernces

• 1、 Jones, Margaret R.,Fast, Caleb D.,Schley, Nathan D.. "Iridium-Catalyzed sp3 C-H Borylation in Hydrocarbon Solvent Enabled by 2,2′-Dipyridylarylmethane Ligands". supporting information. p. 6488 - 6492. Retrieved 2020/04/30.
• 2、 Bellomo, Ana,Zhang, Jiadi,Trongsiriwat, Nisalak,Walsh, Patrick J.. "Additive effects on palladium-catalyzed deprotonative-cross-coupling processes (DCCP) of sp3 C-H bonds in diarylmethanes". . p. 849 - 857. Retrieved 2013/03/28.