phenylhydroxamoyl chloride

Base Information

• Chemical Name: phenylhydroxamoyl chloride
• CAS No.: 934-16-7
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.584
• Mol file: 934-16-7.mol

Synonyms:phenylhydroxamoyl chloride

Chemical Property of phenylhydroxamoyl chloride

Chemical Property:

• Boiling Point: 275.8±23.0 °C(Predicted)
• Density: 1.21±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Z-Benzohydroximoyl Chloride is an intermediate in the synthesis of Oxacillin Sodium Salt (O758503). Oxacillin sodium salt is a narrow spectrum beta-lactam antibiotic. It can be used in analytical study of combination of reversed phase liquid chromatography and zwitterion exchange-reversed phase-hydrophilic interaction mixed-mode liquid chromatography coupled with mass spectrometry for anal. of antibiotics and their impurities.

Technology Process of phenylhydroxamoyl chloride

There total 9 articles about phenylhydroxamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → phenylhydroxamoyl chloride (934-16-7)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 87.0%

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) + aqueous NaCl → phenylhydroxamoyl chloride (934-16-7)

Guidance literature:

With N-chloro-succinimide; pyridine; In chloroform;

Reference yield: 85.0%

Benzaldoxime (932-90-1) → phenylhydroxamoyl chloride (934-16-7)

Guidance literature:

With N-chloro-succinimide; In dichloromethane;

DOI:10.1016/j.bmcl.2006.08.031

upstream raw materials:

C₉H₇Cl₂NO₂

Benzaldoxime

benzaldehyde

syn-benzaldehyde oxime

Downstream raw materials:

6-Chloro-3-phenyl-3a,5,6,6a-tetrahydro-thieno[2,3-d]isoxazole 4,4-dioxide

6-Bromo-3-phenyl-3a,5,6,6a-tetrahydro-thieno[2,3-d]isoxazole 4,4-dioxide

(3aS,9aR)-9-Methyl-3-phenyl-3a,4,9,9a-tetrahydro-isoxazolo[5,4-b]quinoline-4-carbonitrile

5-pentyl-3-phenyl-2-isoxazoline

Refernces

• 1、 Zhang, Weigang,Zou, Zhenlei,Wang, Yuanheng,Wang, Yi,Liang, Yong,Wu, Zhengguang,Zheng, Youxuan,Pan, Yi. "Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters". supporting information. p. 624 - 627. Retrieved 2018/12/13.
• 2、 Boghi, Michele,Hall, Dennis G.. "Valdecoxib: Vs. borazavaldecoxib: Isoxazole BN/CC isosterism as a case study in designing and stabilizing boron heterocycles". supporting information. p. 4849 - 4856. Retrieved 2018/07/13.