C₁₃H₁₃BrO₂

Base Information

• Chemical Name: C₁₃H₁₃BrO₂
• CAS No.: 1383470-52-7
• Molecular Formula: C₁₃H₁₃BrO₂
• Molecular Weight: 281.149
• Mol file: 1383470-52-7.mol

Synonyms:C₁₃H₁₃BrO₂

Chemical Property of C₁₃H₁₃BrO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₃BrO₂

There total 2 articles about C₁₃H₁₃BrO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetic anhydride (108-24-7) + 1-(4-Bromo-phenyl)-2-methyl-buta-2,3-dien-1-ol (138895-09-7) → C13H13BrO2 (1383470-52-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1039/c2cc32015k

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → C13H13BrO2 (1383470-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: indium; ammonium chloride / tetrahydrofuran; water / 0 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; indium; ammonium chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.tetlet.2015.12.098

Reference yield: 47.0%

C14H15NO (1333068-32-8) + C13H13BrO2 (1383470-52-7) → C25H22BrN (1383470-58-3)

Guidance literature:

With palladium dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h; stereoselective reaction;

DOI:10.1039/c2cc32015k

upstream raw materials:

acetic anhydride

1-(4-Bromo-phenyl)-2-methyl-buta-2,3-dien-1-ol

4-bromo-benzaldehyde

Downstream raw materials:

C₂₅H₂₂BrN

Refernces

• 1、 Alcaide, Benito,Almendros, Pedro,Alonso, Jose M.,Fernandez, Israel. "Palladium-catalyzed carbocyclization-cross-coupling reactions of two different allenic moieties: Synthesis of 3-(buta-1,3-dienyl) carbazoles and mechanistic insights". supporting information; experimental part. p. 6604 - 6606. Retrieved 2012/08/08.