Technology Process of C47H89N3O8
There total 23 articles about C47H89N3O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C45H86N2O9; trifluoroacetic acid;
In
dichloromethane;
6-(tert-butoxycarbonylamino)hexanoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
trifluoroacetic acid;
In
dichloromethane;
Further stages.;
DOI:10.1016/j.bmcl.2007.03.084
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 80 percent / NaH / dimethylformamide / 130 °C
2.1: 90 percent / I2; Ph3P; imidazole / CH2Cl2
3.1: Bu2SnO / CHCl3; methanol / Heating
3.2: 79 percent / CsF / dimethylformamide
4.1: 90 percent / iPr2NEt / CH2Cl2
5.1: LDA / tetrahydrofuran
5.2: tetrahydrofuran
6.1: H2 / Pd(OH)2 / ethanol / 40 °C
7.1: Et3N
8.1: DBU
9.1: CH2Cl2
9.2: 41 percent / EDCI; HOBt; i-Pr2NEt / TFA / CH2Cl2
With
1H-imidazole; hydrogen; iodine; sodium hydride; di(n-butyl)tin oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
5.2: aldol reaction;
DOI:10.1016/j.bmcl.2007.03.084
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: aq. NaHCO3
2.1: 90 percent / DIBAL-H / CH2Cl2 / -78 °C
3.1: LDA / tetrahydrofuran
3.2: tetrahydrofuran
4.1: H2 / Pd(OH)2 / ethanol / 40 °C
5.1: Et3N
6.1: DBU
7.1: CH2Cl2
7.2: 41 percent / EDCI; HOBt; i-Pr2NEt / TFA / CH2Cl2
With
hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
3.2: aldol reaction;
DOI:10.1016/j.bmcl.2007.03.084