2,2-difluoroethyl ethyl ether

Base Information

• Chemical Name: 2,2-difluoroethyl ethyl ether
• CAS No.: 372-55-4
• Molecular Formula: C₄H₈F₂O
• Molecular Weight: 110.104
• Mol file: 372-55-4.mol

Synonyms:2,2-difluoroethyl ethyl ether

Chemical Property of 2,2-difluoroethyl ethyl ether

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-difluoroethyl ethyl ether

There total 2 articles about 2,2-difluoroethyl ethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

difluoromethyl copper + ethyl chloromethyl ether (3188-13-4) → 2,2-difluoroethyl ethyl ether (372-55-4) + 1,1,2,2-tetrafluoroethane (359-35-3) + (Z)-1,2-difluoro-ethene (1630-77-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1016/j.jfluchem.2007.05.015

Reference yield:

2-bromo-1,1-difluoroethane (359-07-9) → 2,2-difluoroethyl ethyl ether (372-55-4) + Vinylidene fluoride (75-38-7)

Guidance literature:

With potassium ethoxide;

Reference yield:

2,2-difluoroethyl ethyl ether (372-55-4) → Difluoroacetic acid (381-73-7)

Guidance literature:

Oxydation;

upstream raw materials:

2-bromo-1,1-difluoroethane

ethyl chloromethyl ether

Downstream raw materials:

Difluoroacetic acid

Refernces