Phenol, 3,6-difluoro-2-methoxy-

Base Information

• Chemical Name: Phenol, 3,6-difluoro-2-methoxy-
• CAS No.: 75626-22-1
• Molecular Formula: C7H6 F2 O2
• Molecular Weight: 160.12
• Hs Code.: 2909500000
• Mol file: 75626-22-1.mol

Synonyms:1,4-Difluoro-2-methoxy-3-hydroxybenzene;3,6-Difluoroguaiacol

Chemical Property of Phenol, 3,6-difluoro-2-methoxy-

Chemical Property:

• PSA: 29.46000
• LogP: 1.67900

Purity/Quality:

97% ^*data from raw suppliers

3,6-Difluoro-2-methoxyphenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-Difluoroguaiacol is a reactant used in the synthesis of trimetoquinol derivatives as β-agonist and thromboxane A2 (TXA2) antagonist.

Technology Process of Phenol, 3,6-difluoro-2-methoxy-

There total 5 articles about Phenol, 3,6-difluoro-2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 2,5-difluoroanisole (75626-17-4) → 3,6-difluoro-2-hydroxyanisole (75626-22-1)

Guidance literature:

With n-butyllithium; dihydrogen peroxide; In hexane;

Reference yield:

para-difluorobenzene (540-36-3) → 3,6-difluoro-2-hydroxyanisole (75626-22-1)

Guidance literature:

Multi-step reaction with 3 steps

2: 89 percent / K₂CO₃ / acetone / 2 h / Heating

With potassium carbonate; In acetone;

DOI:10.1021/jo00314a054

Reference yield:

2,5-difluorophenol (2713-31-7) → 3,6-difluoro-2-hydroxyanisole (75626-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃ / acetone / 2 h / Heating

With potassium carbonate; In acetone;

DOI:10.1021/jo00314a054

upstream raw materials:

2,5-difluoroanisole

para-difluorobenzene

2,5-difluorophenol

Trimethyl borate

Downstream raw materials:

<2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine

<2-(2,5-difluoro-3,4-dimethoxyphenyl)ethyl>amine hydrobromide

(2,5-Difluoro-3,4-dimethoxy-phenyl)-acetonitrile

1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene

Refernces

• 1、 -. "Cephalosporins". . . Retrieved 2008/06/13.