ethyl-benzyl-malonic acid

Base Information

• Chemical Name: ethyl-benzyl-malonic acid
• CAS No.: 4379-25-3
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 4379-25-3.mol

Synonyms:ethyl-benzyl-malonic acid

Chemical Property of ethyl-benzyl-malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-benzyl-malonic acid

There total 4 articles about ethyl-benzyl-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl ester of benzylethylmalonic acid (76154-00-2) → ethyl-benzyl-malonic acid (4379-25-3)

Guidance literature:

With potassium hydroxide;

Reference yield:

ethyl diethyl malonate (133-13-1) → ethyl-benzyl-malonic acid (4379-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h

2: aq. KOH / ethanol / 24 h / Heating

With potassium hydroxide; sodium hydride; In ethanol;

DOI:10.1016/S0957-4166(00)86152-2

Reference yield:

benzyl bromide (100-39-0) → ethyl-benzyl-malonic acid (4379-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere

1.2: 19 h / Inert atmosphere; Reflux

2.1: sodium hydroxide; water / ethanol / 24 h / Reflux

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2020.130984

upstream raw materials:

diethyl ester of benzylethylmalonic acid

benzyl chloride

ethyl diethyl malonate

benzyl bromide

Downstream raw materials:

methyl 3-phenyl-2-ethylpropionate

(2S)-2-Benzyl-1-butanol

(R)-2-(phenylmethyl)butanol

2-benzyl butanol

Refernces

• 1、 Colombo, M.,Amici, M. De,Micheli, C. De,Pitre, D.,Carrea, G.,Riva, S.. "CHEMOENZYMATIC SYNTHESIS OF THE ENANTIOMERS OF IOPANOIC ACID". . p. 1021 - 1030. Retrieved 2007/10/02.