Technology Process of 2-(7-benzyl-3-cyclohexyl-7H-pyrrolo[2,3-b]pyridin-2-yl)-5-methoxybenzaldehyde
There total 6 articles about 2-(7-benzyl-3-cyclohexyl-7H-pyrrolo[2,3-b]pyridin-2-yl)-5-methoxybenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; toluene;
for 5h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; ethanol / 144 h
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 - 22 °C
3.2: 0 - 20 °C
4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 5 h / Heating / reflux
With
pyridinium hydrobromide perbromide; hydrogen; sodium hydride; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); 20% Pd(OH)2 on carbon;
In
tetrahydrofuran; ethanol; water; toluene;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 - 22 °C
2.2: 0 - 20 °C
3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 5 h / Heating / reflux
With
pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; toluene;
3.1: Suzuki Coupling;