N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER

Base Information

• Chemical Name: N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER
• CAS No.: 75290-62-9
• Molecular Formula: C8H11 F3 N2 O4 S
• Molecular Weight: 288.248
• Hs Code.: 2930909899
• Mol file: 75290-62-9.mol

Synonyms:Glycine,N-[N-(trifluoroacetyl)-L-cysteinyl]-, methyl ester;N-(Trifluoroacetyl)cysteinylglycine methyl ester

Chemical Property of N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER

Chemical Property:

• Vapor Pressure: 2.2E-07mmHg at 25°C
• Refractive Index: 1.458
• Boiling Point: 423.7°C at 760 mmHg
• PKA: 8.86±0.10(Predicted)
• Flash Point: 210°C
• PSA: 123.30000
• Density: 1.394g/cm³
• LogP: 0.03430

Purity/Quality:

98%min ^*data from raw suppliers

N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER

There total 4 articles about N-(N-TRIFLUOROACETYL-L-CYSTEINYL)-GLYCINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

bis-N-trifluoroacetylcysteinyl-bis-glycine dimethyl ester (89422-41-3) → N-(trifluoroacetyl)-L-cysteinylglycine methyl ester (75290-62-9)

Guidance literature:

With triphenylphosphine; In 1,2-dimethoxyethane; water; at 23 ℃; for 3h;

DOI:10.1016/S0040-4039(00)77430-2

Reference yield:

N-Trifluoracetyl-L-cystine (402-91-5) → N-(trifluoroacetyl)-L-cysteinylglycine methyl ester (75290-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅ / diethyl ether / 0.5 h / 0 °C

2: 87 percent / tetrahydrofuran / 2 h / 0 - 23 °C

3: 84 percent / Triphenylphosphine / 1,2-dimethoxy-ethane; H₂O / 3 h / 23 °C

With phosphorus pentachloride; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water;

DOI:10.1016/S0040-4039(00)77430-2

Reference yield:

N,N'-Bis-trifluoracetyl-L-cystylchlorid (53267-37-1) → N-(trifluoroacetyl)-L-cysteinylglycine methyl ester (75290-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 2 h / 0 - 23 °C

2: 84 percent / Triphenylphosphine / 1,2-dimethoxy-ethane; H₂O / 3 h / 23 °C

With triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

DOI:10.1016/S0040-4039(00)77430-2

upstream raw materials:

bis-N-trifluoroacetylcysteinyl-bis-glycine dimethyl ester

N-Trifluoracetyl-L-cystine

N,N'-Bis-trifluoracetyl-L-cystylchlorid

Downstream raw materials:

N--N-(trifluoroacetyl)-L-cysteinyl>glycine methyl ester

(E)-hept-2-en-1-ol

Leukotriene D

N--L-cysteinyl>glycine

Refernces

• 1、 -. "4-oxo-benzopyran carboxylic acids". . . Retrieved 2008/06/13.