Psora-4

Base Information

• Chemical Name: Psora-4
• CAS No.: 724709-68-6
• Molecular Formula: C21H18 O4
• Molecular Weight: 1992.994048
• European Community (EC) Number: 635-284-0
• UNII: QDY3FLF2DY
• DSSTox Substance ID: DTXSID10424970
• Nikkaji Number: J2.384.708F
• Pharos Ligand ID: 1ZLWTM3NN36A
• ChEMBL ID: CHEMBL1256851
• Mol file: 724709-68-6.mol

Synonyms:5-(4-phenylbutoxy)psoralen;psora-4

Chemical Property of Psora-4

Chemical Property:

• Vapor Pressure: 1.24E-11mmHg at 25°C
• Melting Point: 98 °C(Solv: methanol (67-56-1); water (7732-18-5))
• Refractive Index: 1.626
• Boiling Point: 537.7°C at 760 mmHg
• Flash Point: 279°C
• PSA: 52.58000
• Density: 1.246g/cm³
• LogP: 4.94090
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 334.12050905
• Heavy Atom Count: 25
• Complexity: 482

Purity/Quality:

98%,99%, ^*data from raw suppliers

Psora4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4
• Description: Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).
• Uses: Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.