Technology Process of 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione
There total 4 articles about 1',3'-dimethyl-3-phenyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
scandium tris(trifluoromethanesulfonate);
In
1,2-dichloro-ethane;
for 24h;
Reflux;
DOI:10.1021/ja110520p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: piperidine; acetic acid / benzene / 16 h / 60 °C
2: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / Reflux
With
piperidine; acetic acid; scandium tris(trifluoromethanesulfonate);
In
1,2-dichloro-ethane; benzene;
DOI:10.1021/ja110520p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / diethyl ether / 3.42 h / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 16 h / Reflux
3: piperidine; acetic acid / benzene / 16 h / 60 °C
4: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / Reflux
With
piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; acetic acid; scandium tris(trifluoromethanesulfonate);
In
diethyl ether; dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja110520p