4-Phenyl-4-Pentenoic Acid

Base Information

• Chemical Name: 4-Phenyl-4-Pentenoic Acid
• CAS No.: 5747-06-8
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Mol file: 5747-06-8.mol

Synonyms:4-phenylpent-4-enoic acid

Chemical Property of 4-Phenyl-4-Pentenoic Acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Phenyl-4-Pentenoic Acid

There total 28 articles about 4-Phenyl-4-Pentenoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyltriphenylphosphonium bromide (1779-49-3) + succinylbenzene (2051-95-8) → 4-phenylpent-4-enoic acid (5747-06-8)

Guidance literature:

Methyltriphenylphosphonium bromide; In tetrahydrofuran; at 20 ℃; for 0.5h;

succinylbenzene; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jacs.6b02840

Reference yield: 94.0%

4-phenylpent-4-enoic acid methyl ester (93863-05-9) → 4-phenylpent-4-enoic acid (5747-06-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

Reference yield: 83.0%

C11H13(2)HO → 4-phenylpent-4-enoic acid (5747-06-8) + C11H11(2)HO2 + C11H11(2)HO2

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 20 ℃; Overall yield = 51 mg; Inert atmosphere;

DOI:10.1021/ja4072145

upstream raw materials:

carbon dioxide

1-bromo-3-phenylbut-3-ene

(4-chlorobut-1-en-2-yl)benzene

acetic acid

Downstream raw materials:

4-phenylpent-4-enoyl chloride

5-methyl-5-phenyl-dihydro-furan-2-one

(5S)-5-methyl-5-phenyldihydrofuran-2(3H)-one

(R)-5-methyl-5-phenyl-3,4-dihydro(5H)-furan-2-one

Refernces

• 1、 Andreasson, M?ns,Erdelyi, Mate,Németh, Flóra Boróka,Pápai, Imre,Sethio, Daniel,von der Heiden, Daniel. "Are bis(pyridine)iodine(i) complexes applicable for asymmetric halogenation?". supporting information. p. 8307 - 8323. Retrieved 2021/10/12.
• 2、 Felipe-Blanco, Diego,Gonzalez-Gomez, Jose C.. "Metal-Free Arylation-Lactonization Sequence of γ-Alkenoic Acids Using Anilines as Aryl Radical Precursors". supporting information. p. 7735 - 7744. Retrieved 2019/12/24.