Cyclohexanone, 2-((4-hydroxyphenyl)methyl)-

Base Information Edit

Chemical Name:Cyclohexanone, 2-((4-hydroxyphenyl)methyl)-
CAS No.:22081-10-3
Molecular Formula:C13H16 O2
Molecular Weight:204.269
Hs Code.:
DSSTox Substance ID:DTXSID20944710
Nikkaji Number:J3.598.979J
Mol file:22081-10-3.mol

Synonyms:Cyclohexanone, 2-((4-hydroxyphenyl)methyl)-;22081-10-3;2-(4-Hydroxybenzyl)cyclohexanone;2-[(4-hydroxyphenyl)methyl]cyclohexan-1-one;SCHEMBL7866022;DTXSID20944710;2-(4-hydroxybenzyl)-1-cyclohexanone;AKOS018661590;J3.598.979J

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanone, 2-((4-hydroxyphenyl)methyl)- Edit

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:204.115029749
Heavy Atom Count:15
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(=O)C(C1)CC2=CC=C(C=C2)O

Technology Process of Cyclohexanone, 2-((4-hydroxyphenyl)methyl)-

There total 6 articles about Cyclohexanone, 2-((4-hydroxyphenyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

: 37722-64-8
2-(4-methoxybenzyl)cyclohexan-1-one

: 22081-10-3
2-(4-Hydroxybenzyl)-1-cyclohexanone

Guidance literature:: With hydrogen bromide; In acetic anhydride;
DOI:10.1135/cccc19812573

Reference yield:

: 1125-99-1
1-(1-Cyclohexen-1-yl)pyrrolidine

: 22081-10-3
2-(4-Hydroxybenzyl)-1-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h

2: 55.2 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

With water; hydrogen bromide; acetic anhydride;
DOI:10.1002/hlca.19940770507

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 22081-10-3
2-(4-Hydroxybenzyl)-1-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 64.2 percent / p-TsOH / benzene / Heating; azeotropic dist.

2: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h

3: 55.2 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

With water; hydrogen bromide; acetic anhydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1002/hlca.19940770507