2-Amino-2-(4-aminophenyl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(4-aminophenyl)acetic acid
• CAS No.: 75176-85-1
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Hs Code.: 2922499990
• European Community (EC) Number: 804-256-1
• Mol file: 75176-85-1.mol

Synonyms:75176-85-1;2-amino-2-(4-aminophenyl)acetic acid;4-AMINOPHENYLGLYCINE;SCHEMBL5329159;2-amino-2-(4-aminophenyl)aceticacid;AMINO(4-AMINOPHENYL)ACETIC ACID;N14372

Chemical Property of 2-Amino-2-(4-aminophenyl)acetic acid

Chemical Property:

• Boiling Point: 436.4 °C at 760 mmHg
• Flash Point: 217.7 °C
• PSA: 89.34000
• Density: 1.358 g/cm³
• LogP: 1.63470
• Storage Temp.: 2-8°C
• XLogP3: -2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-(4-aminophenyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(C(=O)O)N)N

Technology Process of 2-Amino-2-(4-aminophenyl)acetic acid

There total 10 articles about 2-Amino-2-(4-aminophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (4-nitrophenyl)acetate (2945-08-6) → 2-amino-2-(4-aminophenyl)acetic acid (75176-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / ethyl nitrite, NaOEt / tetrahydrofuran / 0.5 h / Ambient temperature

2: 68 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

3: aq. HCl / 24 h / 50 °C

With hydrogenchloride; ethyl nitrite; hydrogen; sodium ethanolate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

Reference yield:

ethyl 2-(4-nitrophenyl)-2-oximinoacetate (28899-11-8) → 2-amino-2-(4-aminophenyl)acetic acid (75176-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

2: aq. HCl / 24 h / 50 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

5-(4-amino-phenyl)-3-methyl-3H-imidazol-4-ylamine → 2-amino-2-(4-aminophenyl)acetic acid (75176-85-1)

Guidance literature:

With hydrogenchloride; at 170 ℃;

upstream raw materials:

5-(4-amino-phenyl)-1⁽³⁾H-imidazol-4-ylamine

hydrogenchloride

methyl (4-nitrophenyl)acetate

ethyl 2-(4-nitrophenyl)-2-oximinoacetate

Refernces

• 1、 -. "7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids". . . Retrieved 2008/06/13.