6-(phenyl)-2-naphthoic acid methyl ester

Base Information

• Chemical Name: 6-(phenyl)-2-naphthoic acid methyl ester
• CAS No.: 904688-59-1
• Molecular Formula: C₁₈H₁₄O₂
• Molecular Weight: 262.308
• Mol file: 904688-59-1.mol

Synonyms:6-(phenyl)-2-naphthoic acid methyl ester

Chemical Property of 6-(phenyl)-2-naphthoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-(phenyl)-2-naphthoic acid methyl ester

There total 12 articles about 6-(phenyl)-2-naphthoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 6-bromo-2-naphthoate (33626-98-1) + phenylboronic acid (98-80-6) → 6-(phenyl)-2-naphthoic acid methyl ester (904688-59-1)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; Catalytic behavior; Inert atmosphere; Irradiation;

DOI:10.1039/c5cy01330e

Reference yield: 98.0%

methyl 6-(dimethylsulfamayl)oxy-2-naphthoate (1201594-29-7) + phenylboronic acid (98-80-6) → 6-(phenyl)-2-naphthoic acid methyl ester (904688-59-1)

Guidance literature:

With C₄₆H₆₄ClPPd; potassium carbonate; In methanol; toluene; at 20 ℃; for 4h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.6b02330

Reference yield: 95.0%

C16H19O6P (1279101-97-1) + phenylboronic acid (98-80-6) → 6-(phenyl)-2-naphthoic acid methyl ester (904688-59-1)

Guidance literature:

With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; In 1,4-dioxane; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo2000034

upstream raw materials:

methyl 6-bromo-2-naphthoate

phenylboronic acid

methyl 6-(pivaloyloxy)-2-naphthoate

triphenylboroxine

Downstream raw materials:

6-phenyl-2-naphthoic acid

6-phenylnaphthalene-2-carbohydrazide

N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-6-phenyl-2-naphthohydrazide

Refernces

• 1、 Xiong, Baojian,Li, Yue,Wei, Yin,Kramer, S?ren,Lian, Zhong. "Dual Nickel-/Palladium-Catalyzed Reductive Cross-Coupling Reactions between Two Phenol Derivatives". supporting information. p. 6334 - 6338. Retrieved 2020/09/02.
• 2、 Melvin, Patrick R.,Hazari, Nilay,Beromi, Megan Mohadjer,Shah, Hemali P.,Williams, Michael J.. "Pd-Catalyzed Suzuki-Miyaura and Hiyama-Denmark Couplings of Aryl Sulfamates". supporting information. p. 5784 - 5787. Retrieved 2016/11/29.