3-benzyloxy-2,4-dimethoxy-β-nitrostyrene

Base Information

• Chemical Name: 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene
• CAS No.: 121949-62-0
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.326
• Mol file: 121949-62-0.mol

Synonyms:3-benzyloxy-2,4-dimethoxy-β-nitrostyrene

Chemical Property of 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene

There total 3 articles about 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

nitromethane (75-52-5) + 3-(benzyloxy)-2,4-dimethoxybenzaldehyde (20321-46-4) → 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene (121949-62-0)

Guidance literature:

With methylamine hydrochloride; sodium acetate; for 16h; Ambient temperature;

DOI:10.1002/jhet.5570250557

Reference yield:

3-hydroxy-2,4-dimethoxy benzaldehyde (32246-34-7) → 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene (121949-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Na₂CO₃ / ethanol / 24 h / Heating

2: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature

With methylamine hydrochloride; sodium acetate; sodium carbonate; In ethanol;

DOI:10.1002/jhet.5570250557

Reference yield:

benzyl chloride (100-44-7) → 3-benzyloxy-2,4-dimethoxy-β-nitrostyrene (121949-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Na₂CO₃ / ethanol / 24 h / Heating

2: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature

With methylamine hydrochloride; sodium acetate; sodium carbonate; In ethanol;

DOI:10.1002/jhet.5570250557

upstream raw materials:

nitromethane

3-(benzyloxy)-2,4-dimethoxybenzaldehyde

3-hydroxy-2,4-dimethoxy benzaldehyde

benzyl chloride

Downstream raw materials:

6-benzyloxy-1-(5'-benzyloxy-2'-bromobenzyl)-5,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

1-(5'-benzyloxy-2'-bromobenzylidene)-6-benzyloxy-2-carbethoxy-5,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

1-(2'-bromo-5'-hydroxybenzyl)-5,7-dimethoxy-6-hydroxy-3,4-dihydroisoquinoline hydrochloride

5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide

Refernces