Technology Process of 1,3-Dioxolane, 2,2-dimethyl-4-(1-propynyl)-, (4R)- (9CI)
There total 2 articles about 1,3-Dioxolane, 2,2-dimethyl-4-(1-propynyl)-, (4R)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-(+)-4-(2,2-Dibromoethenyl)-2,2-dimethyl-1,3-dioxolane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - -20 ℃;
for 3h;
methyl iodide;
In
tetrahydrofuran; hexane;
at -20 - 20 ℃;
Further stages.;
DOI:10.1039/b209573d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Zn; triphenylphosphine / CH2Cl2 / 48 h / 0 °C
1.2: 61 percent / CH2Cl2 / 2 h
2.1: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - -20 °C
2.2: tetrahydrofuran; hexane / -20 - 20 °C
With
n-butyllithium; triphenylphosphine; zinc;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Corey-Fuchs reaction;
DOI:10.1039/b209573d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / aq. AcOH / 4 h / 20 °C
2: 814 mg / sulfuric acid / 1 h / 20 °C
3: 10 percent / potassium permanganate; MgSO4; NaHCO3 / acetone; H2O / 0.33 h / 20 °C
4: H2O; aq. phosphate buffer; NaCl / 36 h / pH 6.5
With
potassium permanganate; phosphate buffer; sulfuric acid; water; sodium hydrogencarbonate; magnesium sulfate; acetic acid; sodium chloride;
In
water; acetone;
DOI:10.1002/anie.200353150
