N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester

Base Information

• Chemical Name: N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester
• CAS No.: 174813-34-4
• Molecular Formula: C₁₁H₁₃FN₂O₃
• Molecular Weight: 240.234
• Mol file: 174813-34-4.mol

Synonyms:N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester

Chemical Property of N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester

There total 1 articles about N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one (394-32-1) + ethylhydrazine carboxylate (4114-31-2) → N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester (174813-34-4)

Guidance literature:

In propan-1-ol; for 24h; Heating;

DOI:10.1080/00397919608003863

Reference yield: 72.0%

N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester (174813-34-4) → 2-Acetyl-4-fluoro-benzoic acid ethyl ester (174813-38-8)

Guidance literature:

With lead(IV) acetate; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1080/00397919608003863

Reference yield:

N'-[1-(5-Fluoro-2-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester (174813-34-4) → 2-(4-Chloro-2-fluoro-5-hydroxy-phenyl)-5-fluoro-3-methylene-2,3-dihydro-isoindol-1-one (174813-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / lead tetraacetate / tetrahydrofuran / 4 h / Ambient temperature

2: 30 percent / acetic acid / 1,2-dichloro-benzene / 24 h / Heating

With lead(IV) acetate; acetic acid; In tetrahydrofuran; 1,2-dichloro-benzene;

DOI:10.1080/00397919608003863

upstream raw materials:

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

ethylhydrazine carboxylate

Downstream raw materials:

2-Acetyl-4-fluoro-benzoic acid ethyl ester

2-(4-Chloro-2-fluoro-5-hydroxy-phenyl)-5-fluoro-3-methylene-2,3-dihydro-isoindol-1-one

Refernces