3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride

Base Information

• Chemical Name: 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride
• CAS No.: 1508268-95-8
• Molecular Formula: C₂₀H₂₀N₂O₅*ClH
• Molecular Weight: 404.85
• Mol file: 1508268-95-8.mol

Synonyms:3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride

Chemical Property of 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride

There total 4 articles about 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(tert-butoxycarbonyl)-3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine (1508268-94-7) → 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride (1508268-95-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Cooling with ice; Inert atmosphere;

DOI:10.1021/bc400325n

Reference yield:

N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine (1508268-93-6) → 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride (1508268-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; dihydrogen peroxide / ethanol / 6 h / Cooling with ice; Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / Cooling with ice; Inert atmosphere

With hydrogenchloride; dihydrogen peroxide; sodium hydroxide; In 1,4-dioxane; ethanol;

DOI:10.1021/bc400325n

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → 3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride (1508268-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / nitrobenzene

2: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

3: sodium hydroxide; dihydrogen peroxide / ethanol / 6 h / Cooling with ice; Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / Cooling with ice; Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; dihydrogen peroxide; sodium hydroxide; In 1,4-dioxane; ethanol; water; nitrobenzene;

DOI:10.1021/bc400325n

upstream raw materials:

N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-hydroxyphenyl)-L-alanine

N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine

N-(tert-butoxycarbonyl)-3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine

L-tyrosine

Downstream raw materials:

3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Refernces